Isoindolinone enantiomers having affinity for the dopamine D4 receptor

T R Belliotti; W A Brink; S R Kesten; J R Rubin; D J Wustrow; K T Zoski; S Z Whetzel; A E Corbin; T A Pugsley; T G Heffner; L D Wise

doi:10.1016/s0960-894x(98)00252-2

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. doi: 10.1016/s0960-894x(98)00252-2.

Authors

T R Belliotti¹, W A Brink, S R Kesten, J R Rubin, D J Wustrow, K T Zoski, S Z Whetzel, A E Corbin, T A Pugsley, T G Heffner, L D Wise

Affiliation

¹ Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.

PMID: 9873377
DOI: 10.1016/s0960-894x(98)00252-2

Abstract

PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.

MeSH terms

Animals
Indoles / chemistry*
Indoles / pharmacology*
Motor Activity / drug effects
Rats
Receptors, Dopamine D2 / drug effects*
Receptors, Dopamine D4
Receptors, Serotonin / metabolism
Stereoisomerism
Structure-Activity Relationship
X-Ray Diffraction

Substances

Drd4 protein, rat
Indoles
Receptors, Dopamine D2
Receptors, Serotonin
Receptors, Dopamine D4